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Products for use in the clinical diagnosis of viral infections, including SARS-CoV-2, the virus that causes COVID-19, by simultaneously measuring multiple analytes from a single sample.
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The V-PLEX COVID-19 Coronavirus Panel 3 IgG Kit is an immunoassay that detects IgG antibodies to SARS-CoV-2 in human serum and plasma It contains a 96-well plate coated with recombinant SARS-CoV-2 antigen detection antibodies standards controls wash buffer substrate and stop solution The assay has a sensitivity of 92 9% and specificity of 98 8% starting 14 days after symptom onset It is intended for the qualitative detection of IgG antibodies that recognize SARS-CoV-2 nucleocapsid protein and spike protein receptor binding domain This can aid in identifying individuals with an adaptive immune response to SARS-CoV-2 indicating recent or prior infection
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The Mesoscale K15579U-2 is a high-performance thermoelectric cooler for photonics and semiconductor applications offering a 15W heat pumping capacity and a 0 C to 70 C range It combines a thermoelectric module fan and heat sink for efficient cooling in a compact 40 x 40 x 12 4mm design Operating on 12VDC it can be controlled via a thermistor or thermostat Its solid-state design ensures high reliability making it ideal for stabilizing laser diode temperatures and cooling detectors
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The Meso Scale Discovery K15653U-4 is a 96-well plate with a carbon electrode sensor for label-free detection of proteins via electrochemiluminescence (ECL) It offers high-sensitivity quantitative analysis and screening with low background and high signal-to-noise ratios The product includes 4 plates each allowing 96 assays Compatible with Meso Scale Discovery instruments and reagents it supports ECL-based immunoassays biomolecular interaction analysis and cell signaling studies featuring high sensitivity broad dynamic range and rapid assay times
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The Mesoscale K15435U-2 is a high-performance thermoelectric cooler for photonics and semiconductor applications offering precise temperature control It has a 15W heat pumping capacity and a 70 C temperature differential The four-stage cascaded design with over 250 thermocouples ensures efficient cooling It operates on a 2 8-3 2V DC input and draws up to 5A The compact design measures 4 4mm in height and 27x27mm in footprint With solid-state operation and no moving parts it offers maintenance-free use ideal for systems needing precision temperature stabilization
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The Meso Scale Discovery V-PLEX COVID-19 Coronavirus Panel 3 IgA Kit is an electrochemiluminescence immunoassay that quantitatively measures IgA antibodies to SARS-CoV-2 in human serum and plasma This 5-plate kit includes reagents for 96 tests and can detect IgA antibodies to the SARS-CoV-2 spike and nucleocapsid proteins The assay has high sensitivity and specificity for detecting previous exposure to SARS-CoV-2 This product requires the MSD QuickPlex SQ120 instrument and provides quantitative results within 3 5 hours
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Results are for the identification of SARS-CoV-2 RNA. The SARS-CoV-2 RNA is generally detectable in upper and lower respiratory specimens, and oral fluids during the acute phaseof infection. Positive results are indicative of the presence of SARS-CoV-2 RNA. Positive results do not rule out bacterial infection or co-infection with other viruses. The agent detected may not be the definite cause of disease.Negative results do not preclude SARS-CoV-2 infection and should not be the sole basis of a patient treatment/management or public health decision.The Quick SARS-CoV-2 Multiplex Kit is intended for use by personnel specifically instructed and trained in the techniques of real-time RT-PCR assays.
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The Mesoscale K15463U-4 is a 4-channel 16-bit 250 kS/s simultaneous sampling data acquisition module It has 4 analog voltage input channels with programmable gain amplifiers anti-aliasing filters and 16-bit ADCs The input voltage range is 10 V It communicates via USB and is compatible with Windows Linux and Mac operating systems The module is bus-powered compact and portable It is well suited for low-frequency data acquisition applications
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The Meso Scale Diagnostics SARS-CoV-2 Panel 2 IgA is an in vitro diagnostic test for the qualitative detection of IgA antibodies to SARS-CoV-2 in human serum and plasma This electrochemiluminescence immunoassay utilizes recombinant SARS-CoV-2 antigens to detect IgA antibodies that bind to the receptor binding domain and nucleocapsid protein The test is intended for use as an aid in identifying individuals with an adaptive immune response to SARS-CoV-2 indicating recent or prior infection Results should be used in conjunction with clinical findings and other laboratory tests This product requires the Meso Scale Discovery MULTI-ARRAY 96-well Plate and MSD Reader
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The Meso Scale Discovery SARS-CoV-2 Panel 1 IgM is an in vitro diagnostic test kit that detects IgM antibodies to SARS-CoV-2 in human serum and plasma This qualitative immunoassay uses electroluminescence technology on patterned arrays for detection of antibodies that bind to the receptor binding domain of the SARS-CoV-2 spike protein The test has high sensitivity and specificity and is intended to aid in identifying individuals with an adaptive immune response to SARS-CoV-2 indicating recent or prior infection The kit includes a 96-well plate coated with antigen detection antibody read buffer wash buffer calibrators and controls
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The Mesoscale K15681U-2 is a high-performance thermoelectric cooler using the Peltier effect for precise temperature control It has a 15W heat pumping capacity and a 68 C temperature differential Key features include a compact 15x15mm footprint solid-state construction with no moving parts and a 0-2A operating current range It requires a heat sink and fan for heat dissipation Designed for temperature control in analytical instrumentation industrial lasers medical diagnostics and semiconductor processing it offers reliable maintenance-free operation with proper thermal management
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An alkaloid active against the F32 chloroquine-sensitive (IC50 0 52 UM) and FcB1 and FcM2 chloroquine-resistant strains of P falciparum (IC50s 0 52 0 8 and 0 49 UM respectively) and reduces parasitemia in a mouse model of P vinckei infection (ED50 18 9 mg/kg per day) decreases LPS-induced increases in TNF-a IL-1B and IL-6 levels and p65 nuclear translocation in RAW 264 7 cells at 5 UM decreases serum levels of IL-10 TNF-a and IL-6 and reduces mortality in a mouse model of LPS-induced endotoxemia inhibits proliferation of various cancer cells (IC50s 2 65-370 ng/ml) induces apoptosis and decreases STAT3 phosphorylation in HSC3 and HSC4 oral cancer cells from 0 1-10 UM and reduces tumor growth in an HSC3 mouse xenograft model at 10 mg/kg per day for 24 days
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The V-PLEX SARS-CoV-2 Panel 27 (ACE2) Kit (5 PL) K15609U-2 is a multiplex immunoassay kit for the qualitative detection of antibodies to SARS-CoV-2 in human serum and plasma It contains reagents for 5 plates to run up to 27 samples The assay uses recombinant SARS-CoV-2 receptor binding domain (RBD) and spike protein S1 antigens to detect IgG IgA and IgM antibodies and provides a semi-quantitative result This can aid in identifying individuals with an adaptive immune response to SARS-CoV-2 indicating recent or prior infection The kit has high sensitivity and specificity and takes approximately 3 hours to run
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The Meso Scale Discovery SARS-CoV-2 S1 RBD N501Y Kit is a research use only immunoassay that detects antibodies generated in response to the SARS-CoV-2 spike protein receptor binding domain containing the N501Y mutation This mutation is present in variants like B 1 1 7 B 1 351 and P 1 The kit contains a plate coated with recombinant SARS-CoV-2 S1 RBD N501Y antigen and all necessary reagents It can quantitatively measure IgG antibodies in serum plasma or other biological fluids in under 3 hours using an electrochemiluminescent detection method The kit has high sensitivity and specificity for assessing immune responses
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The Meso Scale Discovery V-PLEX Plus Chemokine Panel 1 NHP Kit is a multiplex immunoassay for measuring 10 non-human primate chemokines in serum plasma and culture supernatants It includes a 96-well plate with capture antibodies detection antibodies calibrators controls diluent read buffer wash buffer and adhesive plate seals Sensitivity is 0 3-43 pg/mL requiring 25 L of sample Analytes CCL2/MCP-1 CCL3/MIP-1 CCL4/MIP-1 CCL5/RANTES CXCL8/IL-8 CXCL9/MIG CXCL10/IP-10 CXCL11/I-TAC CXCL12/SDF-1 CX3CL1/Fractalkine This assay quantifies chemokine levels efficiently
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The Meso Scale Discovery V-PLEX Mouse Cytokine 30-Plex Kit is an electrochemiluminescent immunoassay for measuring 30 mouse cytokines chemokines and growth factors in various biological fluids It includes a 96-well plate with capture antibodies detection antibodies with an electrochemiluminescent label calibrators controls diluent wash buffer read buffer and plate seals The assay features a dynamic range of 3-4 logs high sensitivity and requires 25-50 L of sample It runs on MSD s SECTOR Imager for efficient cytokine profiling
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